HORDB

ID: hor004474
Uniprot ID: P81733
Protein name: Tachykinin-related peptide 2
Gene name: NA
Organism: Rhyparobia maderae (Madeira cockroach) (Leucophaea maderae)
Family: Tachykinin family
Source: Animal
Expression: Midgut and brain.
Disease: NA
Comments: NA
Taxonomy: Rhyparobia (genus), Oxyhaloinae (subfamily), Blaberidae (family), Blaberoidea (superfamily), Blattodea (order), Dictyoptera (superorder), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Function: Myoactive peptide. Increases the amplitude and frequency of spontaneous contractions and tonus of hindgut muscle.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: 10(-9)M
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-P81733-F1.pdb

hor004474_AF2.pdb

hor004474_ESM.pdb

Mass:	208358	Formula:	C79H128N24O24
Absent amino acids:	CDHIMNQTWY	Common amino acids:	P
pI:	9.69	Basic residues:	3
Polar residues:	4	Hydrophobic residues:	5
Hydrophobicity:	-74.71	Boman Index:	-3837
Half-Life:	4.4 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	51.76
Instability Index:	12915.29	Extinction Coefficient cystines:	0
Absorbance 280nm:	0

PubMed ID: 8897641
Title: Isolation of Five Tachykinin-Related Peptides From the Midgut of the Cockroach Leucophaea Maderae: Existence of N-terminally Extended Isoforms